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QPCT

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QPCT
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesQPCT, GCT, QC, sQC, glutaminyl-peptide cyclotransferase
External IDsOMIM: 607065; MGI: 1917786; HomoloGene: 8238; GeneCards: QPCT; OMA:QPCT - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012413

NM_027455
NM_001316729

RefSeq (protein)

NP_036545

NP_001303658
NP_081731

Location (UCSC)Chr 2: 37.34 – 37.37 MbChr 17: 79.36 – 79.4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glutaminyl-peptide cyclotransferase is an enzyme that in humans is encoded by the QPCT gene.[5][6]

This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115828Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024084Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Song I, Chuang CZ, Bateman RC Jr (Jan 1995). "Molecular cloning, sequence analysis and expression of human pituitary glutaminyl cyclase". J Mol Endocrinol. 13 (1): 77–86. doi:10.1677/jme.0.0130077. PMID 7999256.
  6. ^ a b "Entrez Gene: QPCT glutaminyl-peptide cyclotransferase (glutaminyl cyclase)".

Further reading

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