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ING1

From Wikipedia, the free encyclopedia
ING1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesING1, p24ING1c, p33, p33p33ING1b, p47, p47ING1a, inhibitor of growth family member 1
External IDsOMIM: 601566; MGI: 1349481; HomoloGene: 40119; GeneCards: ING1; OMA:ING1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_198219
NM_001267728
NM_005537
NM_198217
NM_198218

RefSeq (protein)

NP_001254657
NP_005528
NP_937860
NP_937861
NP_937862

Location (UCSC)Chr 13: 110.71 – 110.72 MbChr 8: 11.61 – 11.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Inhibitor of growth protein 1 is a protein that in humans is encoded by the ING1 gene.[5][6][7]

Function

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This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.[7]

One of the isoforms of ING1 (p33(ING1) is involved in the modulation of DNA repair.[8] It appears that p33(ING1) cooperates with p53 in nucleotide excision repair.[8] Also, proliferating cell nuclear antigen (PCNA) interacts with p33(ING1b) in the elimination of UV-damaged cells through the induction of programmed cell death (apoptosis).[9]

Location on Chromosome 13

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ING1 is located near the following genes on Chromosome 13

  • CARKD Carbohydrate Kinase Domain-Containing Protein (Unknown Function)
  • COL4A2: A2 Subunit of type IV collagen
  • RAB20: Potential regulator of Connexin 43 trafficking.
  • CARS2: Mitochondrial Cystienyl-tRNA Synthetase 2

Interactions

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ING1 has been shown to interact with:

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000153487Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045969Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Garkavtsev I, Kazarov A, Gudkov A, Riabowol K (Dec 1996). "Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation". Nature Genetics. 14 (4): 415–20. doi:10.1038/ng1296-415. PMID 8944021. S2CID 10173092.
  6. ^ Garkavtsev I, Demetrick D, Riabowol K (Jul 1997). "Cellular localization and chromosome mapping of a novel candidate tumor suppressor gene (ING1)". Cytogenetics and Cell Genetics. 76 (3–4): 176–8. doi:10.1159/000134539. PMID 9186514.
  7. ^ a b "Entrez Gene: ING1 inhibitor of growth family, member 1".
  8. ^ a b Cheung KJ, Mitchell D, Lin P, Li G (July 2001). "The tumor suppressor candidate p33(ING1) mediates repair of UV-damaged DNA". Cancer Res. 61 (13): 4974–7. PMID 11431327.
  9. ^ Scott M, Bonnefin P, Vieyra D, Boisvert FM, Young D, Bazett-Jones DP, Riabowol K (October 2001). "UV-induced binding of ING1 to PCNA regulates the induction of apoptosis". J Cell Sci. 114 (Pt 19): 3455–62. doi:10.1242/jcs.114.19.3455. PMID 11682605.
  10. ^ a b Vieyra D, Loewith R, Scott M, Bonnefin P, Boisvert FM, Cheema P, Pastyryeva S, Meijer M, Johnston RN, Bazett-Jones DP, McMahon S, Cole MD, Young D, Riabowol K (Aug 2002). "Human ING1 proteins differentially regulate histone acetylation". The Journal of Biological Chemistry. 277 (33): 29832–9. doi:10.1074/jbc.M200197200. PMID 12015309.
  11. ^ Xin H, Yoon HG, Singh PB, Wong J, Qin J (Mar 2004). "Components of a pathway maintaining histone modification and heterochromatin protein 1 binding at the pericentric heterochromatin in Mammalian cells". The Journal of Biological Chemistry. 279 (10): 9539–46. doi:10.1074/jbc.M311587200. PMID 14665632.
  12. ^ a b c d e Kuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D (Feb 2002). "Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)". Molecular and Cellular Biology. 22 (3): 835–48. doi:10.1128/mcb.22.3.835-848.2002. PMC 133546. PMID 11784859.
  13. ^ Leung KM, Po LS, Tsang FC, Siu WY, Lau A, Ho HT, Poon RY (Sep 2002). "The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2". Cancer Research. 62 (17): 4890–3. PMID 12208736.
  14. ^ Garkavtsev I, Grigorian IA, Ossovskaya VS, Chernov MV, Chumakov PM, Gudkov AV (Jan 1998). "The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control". Nature. 391 (6664): 295–8. Bibcode:1998Natur.391..295G. doi:10.1038/34675. PMID 9440695. S2CID 4429461.
  15. ^ Scott M, Bonnefin P, Vieyra D, Boisvert FM, Young D, Bazett-Jones DP, Riabowol K (Oct 2001). "UV-induced binding of ING1 to PCNA regulates the induction of apoptosis". Journal of Cell Science. 114 (Pt 19): 3455–62. doi:10.1242/jcs.114.19.3455. PMID 11682605.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.