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The actress has been on the show since 2014, but is preparing to say goodbye.
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"Krista's creativity, vision and dedicated leadership have allowed Grey's Anatomy and Station 19 to continue to flourish," Shonda Rhimes said in a statement.
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Krista Vernoff will also return as showrunner of the series.
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Dr. Addison Montgomery is headed back to Grey Sloan Memorial.
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Gallagher will play a surgeon with important ties to Meredith's late mom, Ellis.
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Germann is the third series regular to leave the show in Season 17.
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ABC renewed the long-running medical drama and its spinoff series, Station 19.
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Williams' final episode airs later this month on May 20.
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Sagal is joined by a stellar cast, including Andy Garcia and John Corbett, in a new drama based on Erin Brockovich's current life.
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It's a beautiful day to save lives!
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"The system that lets me live and murders Rayshard Brooks is a broken system that must change," Krista Vernoff wrote.
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Something wicked is coming to Seattle...
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"This man lied daily, to our faces, and made a mockery of our country. This is not cause for celebration or celebrity."