- Dennis Quaid
- Ronald Reagan
- Penelope Ann Miller
- Nancy Reagan
- Jon Voight
- Viktor Petrovich
- Kevin Dillon
- Jack Warner
- David Henrie
- Young Reagan
- C. Thomas Howell
- Caspar Weinberger
- Mena Suvari
- Jane Wyman
- Xander Berkeley
- George Schultz
- Lesley-Anne Down
- Margaret Thatcher
- Trevor Donovan
- John Barletta
- Robert Davi
- Leonid Brezhnev
- Kevin Sorbo
- Reverend Cleaver
- Jennifer O'Neill
- Older Nelle Reagan
- Sean McNamara
- Director
- Howard Klausner
- Screenwriter
- Mark Joseph
- Producer
- Kevin Mitchell
- Executive Producer
- Arcade Riley
- Executive Producer
- Travis Mann
- Executive Producer
- Brent Ryan Green
- Executive Producer
- Christian Sebaldt
- Cinematographer
- Clayton Woodhull
- Film Editing
- Jeff Canavan
- Film Editing
- John Coda
- Original Music
- Chris Rose
- Production Design
- Amy Teague
- Set Decoration
- Jenava Burguiere
- Costume Design
- Jack Odell
- Costume Design
- Jennifer Ricchiazzi
- Casting
