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When Season 21 of ABC’s Grey’s Anatomy kicks off on Thursday, Sept. 26 (at 10/9c), Meredith is going to be up to her stethoscope in trouble. You’ll recall that in Season 20’s finale (recapped here), she refused to cave to Catherine’s demand that she hand over her Alzheimer’s research and instead made it public. Quicker than you could call time of death, Mer, Amelia, Teddy and Owen were all given the chop.

greys anatomy season 21 mashup
Grey’s Anatomy Season 21: Everything We Know So Far

“Meredith feels very responsible [for them being pink-slipped],” showrunner Meg Marinis tells TVLine, “especially because one of them is Amelia, who is family to her and went along on this ride with her. But Meredith made a huge decision in walking away from Catherine, and that is definitely going to have huge consequences” going forward.

Has it occurred to Meredith that she could just rally the rest of Grey Sloan’s co-owners and give Catherine the boot? “Given her track record, I’m sure every thought like that is going through Meredith’s head,” Marinis laughs, adding, “Her rivalry with Catherine is one of my favorite things to write. [Ellen Pompeo and Debbie Allen] are both incredible actors and play so well off one another.”

On a lighter note, Mer finally seems to be on the same page with significant other Nick. “She made a big step at the end of last season by kind of agreeing to let him in on all of her drastic life changes,” the EP notes. “He has the ability to also challenge her in ways that previous love interests haven’t done since Derek, so that adds a new dynamic that’s really fun.”