Atiprosin: Difference between revisions
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{{Short description|Chemical compound}} |
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{{Drugbox |
{{Drugbox |
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| image = Atiprosin_structure.png |
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| verifiedrevid = 458780782 |
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| image = Atiprosin Structure.svg |
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| width = |
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<!--Clinical data--> |
<!--Clinical data--> |
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| tradename = |
| tradename = |
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| legal_status = |
| legal_status = |
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| routes_of_administration = Oral |
| routes_of_administration = Oral |
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<!--Identifiers--> |
<!--Identifiers--> |
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| CAS_number_Ref = {{cascite|changed|??}} |
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| CAS_number = |
| CAS_number = 89303-63-9 |
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| ATC_prefix = none |
| ATC_prefix = none |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChI = 1S/C20H29N3/c1-5-21-12-13-22(14(2)3)18-10-11-23-17-9-7-6-8-16(17)15(4)19(23)20(18)21/h6-9,14,18,20H,5,10-13H2,1-4H3/t18-,20+/m1/s1 |
| StdInChI = 1S/C20H29N3/c1-5-21-12-13-22(14(2)3)18-10-11-23-17-9-7-6-8-16(17)15(4)19(23)20(18)21/h6-9,14,18,20H,5,10-13H2,1-4H3/t18-,20+/m1/s1 |
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChIKey = WXNVFYIBELASJW-QUCCMNQESA-N |
| StdInChIKey = WXNVFYIBELASJW-QUCCMNQESA-N |
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| PubChem = 71770 |
| PubChem = 71770 |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID = 64808 |
| ChemSpiderID = 64808 |
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| ChEMBL_Ref = {{ebicite|changed|EBI}} |
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| ChEMBL = 2111172 |
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| UNII_Ref = {{fdacite|correct|FDA}} |
| UNII_Ref = {{fdacite|correct|FDA}} |
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| UNII = ALS52889WF |
| UNII = ALS52889WF |
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| synonyms = AY-28,228 |
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<!--Chemical data--> |
<!--Chemical data--> |
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| C=20 | H=29 | N=3 |
| C=20 | H=29 | N=3 |
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| molecular_weight = 311.46 g/mol |
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'''Atiprosin''' ('''AY-28,228''') is an [[antihypertensive]] [[drug|agent]] which acts as a [[binding selectivity|selective]] [[alpha-1 adrenergic receptor|α<sub>1</sub>-adrenergic receptor]] [[receptor antagonist|antagonist]].<ref name="isbn0-412-46630-9">{{cite book | author = David J. Triggle | title = Dictionary of Pharmacological Agents | publisher = Chapman & Hall/CRC | location = Boca Raton | year = 1996 |
'''Atiprosin''' ('''AY-28,228''') is an [[antihypertensive]] [[drug|agent]] which acts as a [[binding selectivity|selective]] [[alpha-1 adrenergic receptor|α<sub>1</sub>-adrenergic receptor]] [[receptor antagonist|antagonist]].<ref name="isbn0-412-46630-9">{{cite book | author = David J. Triggle | title = Dictionary of Pharmacological Agents | publisher = Chapman & Hall/CRC | location = Boca Raton | year = 1996 | isbn = 0-412-46630-9 | url = ://books.google.com/?id=DeX7jgInYFMC&=atiprosin&pg=PA189}}</ref><ref name="pmid3806618">{{cite journal |=Jirkovsky I, Santroch G, Baudy R, Oshiro G | title = Octahydropyrazino[2',3':3,4]pyrido[1,2-a]indoles. A new class of potent antihypertensive agents | journal = Journal of Medicinal Chemistry | volume = 30 | issue = 2 | pages = 388–94 |= 1987 | pmid = 3806618 | doi = 10.1021/jm00385a022}}</ref><ref name="pmid2444771">{{cite journal |=Grimes D, Rimele TJ, Henry DE | title = In vitro isolated tissue studies with atiprosin (AY-28,228): a new antihypertensive compound | journal = Journal of Cardiovascular Pharmacology | volume = 10 | issue = 3 | pages = 249–58 |= 1987 | pmid = 2444771 | doi = 10.1097/00005344-198709000-00001| = }}</ref><ref name="pmid2444784">{{cite journal |=Oshiro G, Wojdan A, Klein M, Metcalf G | title = Antihypertensive and hypotensive actions of atiprosin (AY-28,228) in rats, dogs, and monkeys | journal = Journal of Cardiovascular Pharmacology | volume = 10 | issue = 3 | pages = 341–9 |= 1987 | pmid = 2444784 | doi = 10.1097/00005344-198709000-00014| = }}</ref> It also possesses some [[antihistamine]] activity, though it is some 15-fold weaker in this regard than as an [[alpha blocker]].<ref name="pmid2444771"/> It was never marketed.<ref name="isbn0-412-46630-9"/> |
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== |
== == |
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[[File:Atiprosin.png|450px]]<ref>{{Cite journal|journal=Journal of Medical Chemistry|year=1987|volume=30|issue=2|pages=388–394|last=Jirkovsky|first=Ivo|coauthors=George Santroch, Reinhardt Baudy, George Oshiro|title=Octahydropyrazino[2',3':3,4]pyrido[1,2-a]indoles. A new class of potent antihypertensive agents|doi=10.1021/jm00385a022|pmid=3806618}}</ref> |
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== See also == |
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* [[Prazosin]] |
* [[Prazosin]] |
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* [[Ketanserin]] |
* [[Ketanserin]] |
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== |
==References== |
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{{Reflist}} |
{{Reflist}} |
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==External links== |
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* {{Commonscatinline}} |
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{{Antihypertensives}} |
{{Antihypertensives}} |
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{{Adrenergic receptor modulators}} |
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{{Adrenergics}} |
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{{Histamine receptor modulators}} |
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{{Histaminergics}} |
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{{Tricyclics}} |
{{Tricyclics}} |
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[[Category: |
[[Category: ]] |
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[[Category:Alpha-1 blockers]] |
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[[Category:Antihistamines]] |
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[[Category:Antihypertensive agents]] |
[[Category:Antihypertensive agents]] |
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[[Category:Indoles]] |
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[[Category:Isopropyl compounds]] |
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[[Category:Piperazines]] |
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{{Antihypertensive-stub}} |