BRCA1 |
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Strwythurau |
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PDB | Human UniProt search: PDBe RCSB |
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Rhestr o ddynodwyr PDB |
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1JM7, 1JNX, 1N5O, 1OQA, 1T15, 1T29, 1T2U, 1T2V, 1Y98, 2ING, 3COJ, 3K0H, 3K0K, 3K15, 3PXA, 3PXB, 3PXC, 3PXD, 3PXE, 4IFI, 4IGK, 4JLU, 4OFB, 4U4A, 4Y18, 4Y2G |
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Dynodwyr |
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Cyfenwau | BRCA1, breast cancer 1, early onset, BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PPP1R53, PSCP, RNF53, FANCS, breast cancer 1, DNA repair associated, BRCA1 DNA repair associated, Genes |
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Dynodwyr allanol | OMIM: 113705 HomoloGene: 5276 GeneCards: BRCA1 |
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Ontoleg y genyn |
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Gweithrediad moleciwlaidd | • tubulin binding • metal ion binding • enzyme binding • zinc ion binding • damaged DNA binding • GO:0001948, GO:0016582 protein binding • GO:0001105 transcription coactivator activity • androgen receptor binding • RNA binding • ubiquitin protein ligase binding • GO:0050372 ubiquitin-protein transferase activity • DNA binding • transferase activity • RNA polymerase binding • identical protein binding
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Cydrannau o'r gell | • BRCA1-BARD1 complex • condensed nuclear chromosome • BRCA1-A complex • ubiquitin ligase complex • Cellbilen • nucleoplasm • condensed chromosome • cytoplasm • Cromosom • cnewyllyn cell • lateral element • GO:0009327 protein-containing complex • ribonucleoprotein complex
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Prosesau biolegol | • response to ionizing radiation • centrosome cycle • chromosome segregation • protein K6-linked ubiquitination • intrinsic apoptotic signaling pathway in response to DNA damage • cell cycle • double-strand break repair via nonhomologous end joining • GO:0097285 apoptotic process • regulation of apoptotic process • regulation of gene expression by genetic imprinting • GO:0009373 regulation of transcription, DNA-templated • negative regulation of fatty acid biosynthetic process • transcription, DNA-templated • regulation of transcription by RNA polymerase III • fatty acid biosynthetic process • regulation of DNA methylation • negative regulation of intracellular estrogen receptor signaling pathway • protein autoubiquitination • positive regulation of histone H3-K9 methylation • DNA recombination • positive regulation of angiogenesis • response to estrogen • cellular response to indole-3-methanol • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • GO:0045996 negative regulation of transcription, DNA-templated • positive regulation of protein ubiquitination • androgen receptor signaling pathway • negative regulation of centriole replication • postreplication repair • lipid metabolism • cellular response to tumor necrosis factor • GO:1900404 positive regulation of DNA repair • fatty acid metabolic process • GO:1901313 positive regulation of gene expression • negative regulation of histone H3-K4 methylation • regulation of cell population proliferation • negative regulation of reactive oxygen species metabolic process • positive regulation of vascular endothelial growth factor production • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of histone H4-K20 methylation • DNA double-strand break processing • double-strand break repair via homologous recombination • negative regulation of histone acetylation • protein ubiquitination • positive regulation of histone H3-K4 methylation • GO:0100026 DNA repair • double-strand break repair • positive regulation of histone acetylation • dosage compensation by inactivation of X chromosome • negative regulation of histone H3-K9 methylation • positive regulation of histone H3-K9 acetylation • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • chordate embryonic development • positive regulation of histone H4-K16 acetylation • cellular response to DNA damage stimulus • protein deubiquitination • DNA replication • mitotic G2/M transition checkpoint • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • negative regulation of G0 to G1 transition • transcription by RNA polymerase II • mitotic G2 DNA damage checkpoint signaling • regulation of signal transduction by p53 class mediator
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Sources:Amigo / QuickGO |
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Orthologau |
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Species | Bod dynol | Llygoden |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Lleoliad (UCSC) | n/a | n/a |
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PubMed search | [1] | n/a |
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Wicidata |
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Protein sydd yn cael eu codio yn y corff dynol gan y genyn BRCA1 yw BRCA1 a elwir hefyd yn breast cancer 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi eu lleoli ar yr edefyn ôl o gromosom dynol 17, band 17q21.31.
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mae'r un genyn oedd hi. Hefyd Mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BRCA1.
- IRIS
- PSCP
- BRCAI
- BRCC1
- FANCS
- PNCA4
- RNF53
- BROVCA1
- PPP1R53
- "Diagnostic markers for the detection of ovarian cancer in BRCA1 mutation carriers.". PLoS One. 2017. PMID 29244844.
- "Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer.". Nat Genet. 2017. PMID 29058716.
- "Ovarian Aging in Women With BRCA Germline Mutations.". J Clin Endocrinol Metab. 2017. PMID 28938488.
- "Prevalent somatic BRCA1 mutations shape clinically relevant genomic patterns of nasopharyngeal carcinoma in Southeast Europe.". Int J Cancer. 2018. PMID 28857155.
- "Rapid selection of BRCA1-proficient tumor cells during neoadjuvant therapy for ovarian cancer in BRCA1 mutation carriers.". Cancer Lett. 2017. PMID 28377179.
- ↑ "Human PubMed Reference:".